A Sexy Alex, stage 2: DMSI Journal (now 3.3.2!)

[apollolux]

I'm super curious as well, @Shannon  . I can say for certain that the old medication that was replaced was Lexapro/escitalopram 10mg, an SSRI, and the new one is Cymbalta/duloxetine 60mg, apparently an SSNRI. I don't necessarily know what's different between SSRI and SSNRI other than the inclusion of targeting norepinephrine, but I can say from observation that Lexapro's mirror image, Celexa/citalopram, as used by my twin brother a little over a decade ago really screwed him up and was not helpful to him at all. I only ever gave Lexapro a shot because my doctor insisted that it's different enough from Celexa (which I vehemently refused and will continue to refuse) that I wouldn't have nearly as adverse reactions to it as my brother did with Celexa.

My current theory as a result of having taken Lexapro for almost 4 years is that serotonin reuptake inhibitors of any kind, selective or otherwise, would significantly stuff or otherwise completely negate the neuro-chemical aspects of executing subs like DMSI and maybe others. As of writing this Dec 3 I've only used the Cymbalta for about two months or so, so I don't know yet/don't have any better formed hypothesis on how serotonin-norepinephrine reuptake inhibitors differ. Currently the most prominent side effect of the new med is increased anger and emotional sensitivity. I do admit this is all just conjecture for now and that I don't necessarily have enough relevant domain knowledge to definitively say one way or another "anti-depressants conflict with certain subs," but I would hope that my understanding and presentation of such is reasonable enough to at least point to a direction.